Quais são os benefícios para a saúde e os usos do óleo de cravo?

O óleo de cravo é extraído do cravo. É vapor destilado de botões de cravo que têm um cheiro forte e pungente. É nativo do sudeste da Ásia e tem sido usado para tratar a dor associada a problemas dentários por séculos.

Diz-se que o óleo de cravo possui propriedades antioxidantes, antimicrobianas, antifúngicas, antiinflamatórias e anestésicas (1), (2). Também pode ajudar a tratar doenças de pele, auxiliar na digestão e estimular o sistema imunológico. Este artigo discute os benefícios potenciais para a saúde, usos e efeitos colaterais do óleo de cravo. Leia para saber mais.

12 usos e benefícios do óleo de cravo

1. Pode aliviar a dor de dente

O óleo essencial de cravo pode ajudar a prevenir cáries e a aliviar a dor oral. Tradicionalmente, é usado para aliviar dores de dente. Ele também é usado para emergências dentárias, como inflamação da boca ou da garganta. O óleo de cravo também foi relatado como sendo usado na preparação de certos cremes dentais e enxaguatórios bucais (3). Eugenol, um líquido oleoso aromático extraído do óleo de cravo, é usado como sedativo em procedimentos odontológicos (4). O cravo também tem propriedades anti-placa. Pode inibir o crescimento de bactérias orais que podem causar placa dentária (5).

O óleo essencial de cravo também demonstrou atividade anticariogênica e citotóxica contra um grande número de patógenos orais (6). Eugenol e acetato de eugenila são os dois componentes ativos do óleo essencial de cravo-da-índia que ajudam a prevenir a descalcificação ou erosão dentária (7). O óleo de cravo é mais eficaz contra microrganismos que causam cárie dentária (8).

2. Pode ajudar a tratar doenças de pele e acne

O óleo de cravo atua contra o Propionibacterium acnes, bactéria que causa acne (9). No entanto, mais estudos nesta linha são necessários para chegar a conclusões adicionais.

Um estudo realizado pelo Departamento de Dermatologia de Cairo, Egito, constatou que o óleo de cravo foi eficaz no tratamento tópico do prurido crônico (10).

Outro estudo realizado pelo Hospital Universitário de Mansoura, no Egito, constatou que a aplicação tópica de creme de óleo de cravo pode ajudar no tratamento de fissuras anais crônicas (11).

3. Pode ter propriedades analgésicas

A massagem com óleo de cravo foi encontrada para reduzir efetivamente a dor nas costas em mães pós-parto (12). Diz-se que o óleo de cravo possui propriedades analgésicas que reduzem a dor de dente e as articulações por meio da ativação dos canais de cálcio e cloreto nos linfonodos (13). O eugenol no cravo também tem sido estudado por seus efeitos analgésicos (14). O óleo de cravo também pode aliviar a dor em ratos (15).

Outro estudo conduzido pela Universidade do Kuwait descobriu que o gel de cravo pode ter o potencial de substituir a benzocaína como anestésico tópico (16).

4. Pode ajudar na digestão

O óleo de cravo pode ajudar a aliviar náuseas, vômitos e enjôo, graças às suas propriedades anti-irritantes e calmantes (17). O eugenol do óleo essencial de cravo-da-índia tem a capacidade de estimular a síntese de muco, um importante fator gastroprotetor (18). No entanto, pesquisas adicionais são necessárias para compreender seu uso no tratamento de úlceras gástricas.

5. Pode impulsionar o sistema imunológico

O eugenol do cravo protege as membranas celulares dos danos dos radicais livres e do estresse oxidativo (19). Em um estudo com animais, o óleo também pode exercer um papel protetor contra o estresse oxidativo induzido por radiação (20). Diz-se que o óleo de cravo possui efeitos antiinflamatórios. Um estudo mostrou que o óleo de cravo tem efeito antiinflamatório dose-dependente em ratos Wistar (21). Além disso, descobriu-se que o óleo tinha efeitos antinociceptivos e antipiréticos em ratos (22).

6. Pode ter propriedades antimicrobianas

O óleo essencial de cravo é uma fonte potente de compostos antimicrobianos que atuam especialmente contra patógenos bacterianos (23). O óleo pode ser eficaz em interromper o crescimento de diversos tipos de bactérias e também agir contra patógenos do trato respiratório (24). O óleo de cravo também foi encontrado para agir contra as cepas clínicas de Escherichia coil , uma bactéria específica que é altamente resistente a vários antibióticos (25). Um estudo conduzido pela Seção de Microbiologia e Tecnologia de Frutos do Mar, da Espanha, descobriu que o óleo essencial de cravo matou com eficiência os biofilmes de Staphylococcus aureus (26) .

Além disso, o óleo de cravo atua contra a Candida albicans, que causa aftas, pé de atleta e infecções vaginais por fungos. O eugenol no óleo de cravo pode exercer um efeito anticandida (27). Um estudo conduzido pela Toyama Medical and Pharmaceutical University descobriu que uma combinação de aciclovir Um estudo conduzido pela Toyama Medical and Pharmaceutical University descobriu que uma combinação de aciclovir (um medicamento antiviral) e cravo em ratos poderia tratar a infecção viral herpes simplex (28) Uma mistura de óleo essencial com óleo de cravo pode atenuar significativamente o vírus da gripe. Os vírus tratados com a mistura de óleo tiveram expressão mínima de proteínas virais. Isso significa que o óleo de cravo pode ter a capacidade de combater certos vírus que causam infecções (29).

7. Pode atuar como um repelente de insetos

O óleo de cravo pode atuar como repelente de insetos e prevenir doenças transmitidas por vetores (causadas em humanos por um parasita) (30). Um estudo descobriu que os componentes do óleo essencial de cravo podem ser potencialmente úteis na produção de repelentes corporais de piolhos (31). O óleo de cravo também pode apresentar atividade repelente contra cupins japoneses (32).

Um estudo conduzido pela Universidade Mahidol, na Tailândia, descobriu que o óleo essencial de cravo pode repelir larvas de Leptotrombidium , que são uma espécie de larva. O óleo também pode ser uma alternativa mais segura e barata aos repelentes sintéticos que podem causar efeitos colaterais (33). O óleo essencial de cravo também mostrou repelência contra Leptotrombidium deliense , outra espécie de larva (34). Além disso, uma formulação contendo óleo essencial de cravo mostrou-se eficaz contra o mosquito Aedes aegypti (35).

O eugenol no óleo de cravo também pode funcionar como uma alternativa promissora aos inseticidas comuns (36). Foi descoberto que eugenol, acetato de eugenol e beta-cariofileno, os produtos químicos bioativos do cravo-da-índia, têm a capacidade de repelir formigas vermelhas (37).

8. Pode reduzir a dor de estômago

O eugenol no óleo de cravo foi proposto para ser benéfico para problemas gastrointestinais, como dor abdominal. Também é usado para tratar tosse, catarro e congestão torácica (38). O cravo pode ser usado para reduzir a dor de estômago. No entanto, dados limitados estão disponíveis para apoiar esta afirmação.

9. Pode impulsionar a saúde cardiovascular

Clove oil may help boost cardiovascular health. Traditionally, it is known to improve blood circulation. A rat study showed that the eugenol in the oil dilated cerebral arteries. This, in humans, may mean a reduced risk of stroke (39). In rats, treatment with eugenol could lower blood pressure levels and even slow down the heart rate (40). In another study, high-fructose-fed rats, when given clove essential oil, showed an improvement in fatty liver. The oil could also regulate cholesterol levels in the rats. The study suggests the possible cardioprotective properties of clove oil (41).

In diabetic rats, clove oil could also show cardioprotective effects. This could be because of the oil’s antioxidant properties (42). Another study concludes that eugenol could be therapeutically useful as an antihypertensive agent (43).

10. May Promote Hair Growth

Eugenol is known to stimulate the hair roots. A formulation containing clove oil was found to condition hair and enhance its growth. It could repair the hair shaft (44). However, more studies in this line are needed to reach further conclusions.

11. May Have Anticancer Properties

Eugenol was identified as one of the agents that could have anticancer properties. It may also prevent the proliferation of cancer cells and can help with cancer cell death (apoptosis) (45).

In another study, eugenol could suppress the growth of melanoma or skin cancer. Eugenol treatment could reduce tumor size by 40% and also delayed the growth of tumors (46). The National Toxicology Program based on several long term carcinogenicity studies concluded that eugenol was not carcinogenic to rats (47). Similar observations could be expected in humans as well.

In another study, clove extract was found to inhibit tumor growth. It could be a novel treatment for colorectal cancer (48).

However, it is important to practice caution, as eugenol may also have certain prooxidant properties. The compound may cause allergies and other inflammatory reactions (49).

12. May Act As An Aphrodisiac

In studies on male mice, extracts of clove (along with nutmeg) could enhance sexual behavior (50). In another study, 50% ethanolic extract of clove produced a significant and sustained increase in the sexual activity of normal male rats. The extract also caused no adverse effects (51). However, more studies are warranted in this regard.

These are the major benefits of clove oil. The oil also has other important uses, which we will explore in the following section.

Other Uses of Clove Oil

• Clove oil blended with cinnamon, orange, nutmeg, or vanilla oils can lift one’s spirits. Using this warming blend in a diffuser will soon fill the room and may also relieve stress.
• Anecdotal evidence suggests that sniffing the spicy aroma of cloves reduces drowsiness and fatigue, irritability, and headaches. It may stimulate the mind and also increase memory recall.
• Cloves encourage the loosening of phlegm from the respiratory system. They also promote sweating during fevers, colds, and flu, which can be very healing. Clove oil is often used in remedies for coughs.
• Like many culinary spices, clove may help relax the smooth muscle lining of the digestive tract. A few drops of the oil in water can relieve nausea. Clove tea may help treat diarrhea, gas, bloating, and intestinal spasms.
• Clove oil stimulates circulation and blood flow to the skin. This may help those with cold extremities.
• Clove oil is as effective as oil of oregano in treating athlete’s foot, nail fungus, and other skin problems. It can be applied directly to the skin or nails (unless the skin is sensitive or broken, wherein it must be diluted with extra virgin olive oil or unrefined coconut oil).
• One drop of clove oil applied to the roof of the mouth may relieve headaches. However, more research is warranted in this regard.
• Clove oil is long used in aromatherapy to relieve pain. For general pain relief, add 3 drops of clove oil to 1 teaspoon of coconut oil or extra virgin olive oil. Apply it to the pain areas.
• A band-aid soaked in a few drops of clove oil can help treat warts. Applying the band-aid to warts may help dissolve them if done regularly for a few weeks.

Clove oil is popularly known as a remedy for toothache. Using oil to relieve tooth pain is simple. Check the following section

How To Use Clove Oil To Treat A Toothache?

Dentists use clove oil as an oral anesthetic and also to disinfect root canals. The oil stops the toothache when dropped into the oral cavity. For temporary relief, dip a cotton swab in clove oil and apply it to the affected tooth. Adding a clove or two to a cup of tea can work miracles on a toothache.

Here is how you can use clove oil to relieve your toothache:

• Dilute a few drops of clove oil in an edible carrier oil, such as olive or coconut oils.
• Dab a clean cotton ball into the solution, and allow it to soak in it.
• Avoiding contact with your gums, apply the cotton ball to the sore tooth. It may take a few minutes of application for you to feel the relief.
• Apply every 2 hours or as necessary.

You can use clove oil in various other ways to achieve its benefits. In the following section we have discussed its most popular uses.

How To Use Clove Oil?

Spray

Using the clove oil as a spray is an easy way to add the clove scent to your room. Clove oil possesses antimicrobial properties, and you can also use it as a mild disinfectant.

To make a clove spray:

• Add several drops of clove oil to water. You would need 10 to 15 drops of clove oil per ounce of water to prepare the spray.
• Add it to a spray bottle. Be sure to shake the bottle well before spraying.

Diffuser

You can also use the oil in a diffuser. While diffusing clove oil, carefully follow the instructions that come with the diffuser. Make sure the room is well-ventilated when you diffuse the clove oil.

Topically

You can apply clove oil to your skin to achieve different benefits.

Massage oils

Use 15 drops of clove oil per ounce of carrier oil to create a 2.5 percent solution of massage oil. This solution can be used as a massage oil for pain relief.

Creams, scrubs, or lotions

For use on normal skin, you need 1 to 2.5 percent dilution of clove oil. For sensitive skin, you need 0.5 to 1 percent dilution of the oil. This diluted solution has no aroma and can be used in the preparation of several scrubs, lotions, or creams.

How Do You Use Clove Oil For Hair Growth?

There is not enough information in this regard. But anecdotal evidence suggests that clove oil acts as a natural remedy to promote hair growth as it contains a number of vital vitamins and minerals. Massaging diluted clove oil into your scalp may boost blood circulation. This could ensure more nutrients and oxygen are supplied to your scalp and hair follicles. To experience the benefits of clove essential oil for hair growth, you can indulge in a hot oil treatment or apply a DIY hair mask prepared with clove oil.

Though clove oil is well studied for its benefits, it may not be suitable for all. The oil may cause side effects in some.

Are There Any Side Effects Of Using Clove Oil?

Clove oil may cause local irritation, rare allergic reactions, and contact dermatitis in some individuals. More severe effects include tissue injury and acute onset of seizures, coma, and damage to the liver and kidneys (52). Clove essential oil is generally recognized as a safe substance when consumed in concentrations lower than 1500 mg/kg. The World Health Organization (WHO) established that the daily quantity acceptable of clove per day is 2.5 mg for every kg of body weight in humans (53).

Hepatotoxicity

High doses of eugenol may harm the liver and kidneys, as per some rat studies. Several instances of severe acute liver and kidney injury have been reported after an accidental overdose of eugenol containing herbal products, largely in infants (54), (55).

May Cause Skin irritation

Excess usage of clove oil can cause skin irritation in some people. Eugenol is an effective substance that is incorporated into many dental products. Contact dermatitis due to this chemical is not unusual. However, true serious allergic reactions are extremely rare (56).

As a primary irritant and sensitizer, eugenol is known to cause contact urticaria as well as chronic urticaria (rashes with dangerous swelling) (57). If you are concerned about your sensitivity to this essential oil, do a patch test before using it. Apply a small amount of diluted clove oil to the inside of your elbow. If you notice signs of skin irritation, like redness, itching, or swelling, don’t use clove oil topically.

May Cause Allergies

It is very rare to have an allergic reaction due to clove oil. The eugenol in the oil may cause oral irritation and heat sensation on the tongue (58).

Drug Interactions

Medications that slow blood clotting (anticoagulant/antiplatelet drugs) interact with clove. Hence, avoid using clove oil if you are taking any anticoagulants. Acetyl eugenol, a component of clove oil (Syzygium aromaticum L.), inhibits platelet aggregation in humans. This could lead to bleeding (59), (60).

Avoid using clove oil if you have had a recent major surgery, peptic ulcers, or bleeding disorders, such as hemophilia.

You can buy clove oil from your nearest health store. But before you make a purchase, you need to keep a few things in mind.

What To Look For When Buying Clove Oil

Look for a purity statement on the label

Try to buy 100 percent clove essential oil and look for other ingredients listed (if any).

Don’t go by the marketing hype

Generally, essential oils are not regulated by the Food and Drug Administration (FDA) in the same way as drugs. Hence, you should be more cautious of any oil that claims to cure a specific condition.

Make sure the clove oil is in a dark glass bottle

Light has the potential to damage essential oils. Dark glass helps keep the light out. Always ensure your product comes packaged in a dark glass bottle.

If you can, smell it before buying it

Clove essential oil has a unique fragrance. Smell it before buying. If it does not smell natural, avoid purchasing it.

Conclusion

Clove oil possesses many therapeutic properties and has several health benefits. From dealing with dental problems to treating cardiovascular issues, this essential oil can improve human health in various ways. However, excess usage may cause several side effects. Hence, limit its use and consult your doctor if you experience any adverse effects.

Expert’s Answers For Readers’ Questions

Can you drink clove oil?

Ingestion of clove oil can be dangerous. Clove oil ingestion may result in coma, fits, and acute liver damage (61).

Can clove oil damage teeth?

Clove oil is generally considered safe for teeth.

How often can I use clove oil on my tooth?

If you are suffering from toothache, you can use it every 3-5 hours for relief. If you have multiple pain points in your mouth after a dental procedure, you can add a few drops of clove oil to coconut oil and swirl it in your mouth.

Does clove oil help you sleep?

The oil contains eugenol that is a mild anesthetic. It may aid in sleeping. Apply a few drops of warm clove oil with some carrier oil on your forehead for better sleep.

Can you apply clove oil directly to the skin?

First, do a patch test after diluting the oil with a carrier oil. If there is no reaction, you can apply clove oil to your skin.

How long does clove oil take to work?

Clove oil may soothe a toothache and relieve pain within minutes. It generally takes 5-10 minutes to work.

61 sources

A Stylecraze tem diretrizes rígidas de abastecimento e depende de estudos revisados ​​por pares, instituições de pesquisa acadêmica e associações médicas. Evitamos usar referências terciárias. Você pode aprender mais sobre como garantimos que nosso conteúdo seja preciso e atualizado lendo nossa política editorial.

• Milind, Parle e Khanna Deepa. “Cravo: um tempero campeão.” Int J Res Ayurveda Pharm 2.1 (2011): 47-54.

  www.researchgate.net/publication/267402397_Clove_A_champion_spice

• Cortés-Rojas, Diego Francisco et al. “Cravo (Syzygium aromaticum): uma especiaria preciosa.” Jornal da Ásia-Pacífico de biomedicina tropical vol. 4,2 (2014): 90-6.

  www.ncbi.nlm.nih.gov/pmc/articles/PMC3819475/

• Kumarswamy, A. “Multimodal management of dental pain with focus on alternative medicine: A novel herbal dental gel.” Contemporary clinical dentistry vol. 7,2 (2016): 131-9.

  www.ncbi.nlm.nih.gov/pmc/articles/PMC4906852/

• Kozam, George. “The effect of eugenol on nerve transmission.” Oral Surgery, Oral Medicine, Oral Pathology 44.5 (1977): 799-805.

  www.sciencedirect.com/science/article/abs/pii/0030422077903905

• Kothiwale, Shaila V., et al. “A comparative study of antiplaque and antigingivitis effects of herbal mouthrinse containing tea tree oil, clove, and basil with commercially available essential oil mouthrinse.” Journal of Indian Society of Periodontology 18.3 (2014): 316.

  www.ncbi.nlm.nih.gov/pmc/articles/PMC4095623/

• Kouidhi, Bochra, Tarek Zmantar, and Amina Bakhrouf. “Anticariogenic and cytotoxic activity of clove essential oil (Eugenia caryophyllata) against a large number of oral pathogens.” Annals of microbiology 60.4 (2010): 599-604.

  link.springer.com/article/10.1007/s13213-010-0092-6

• Marya, Charu M et al. “In vitro inhibitory effect of clove essential oil and its two active principles on tooth decalcification by apple juice.” International journal of dentistry vol. 2012 (2012): 759618.

  www.ncbi.nlm.nih.gov/pmc/articles/PMC3432374/

• Kanth, M Rajini et al. “Efficacy of Specific Plant Products on Microorganisms Causing Dental Caries.” Journal of clinical and diagnostic research: JCDR vol. 10,12 (2016): ZM01-ZM03. doi:10.7860/JCDR/2016/19772.9025

  www.ncbi.nlm.nih.gov/pmc/articles/PMC5296592/

• Fu, YuJie, et al. “The antibacterial activity of clove essential oil against Propionibacterium acnes and its mechanism of action.” Archives of dermatology 145.1 (2009): 86-88.

  jamanetwork.com/journals/jamadermatology/article-abstract/711838

• Ibrahim IM, Elsaie ML, Almohsen AM, Mohey-Eddin MH. Effectiveness of topical clove oil on symptomatic treatment of chronic pruritus. J Cosmet Dermatol . 2017;16(4):508‐511.

  pubmed.ncbi.nlm.nih.gov/28382655/

• Elwakeel HA, Moneim HA, Farid M, Gohar AA. Clove oil cream: a new effective treatment for chronic anal fissure. Colorectal Dis . 2007;9(6):549‐552.

  pubmed.ncbi.nlm.nih.gov/17573751/

• Nethravathi, V., and V. Vijaitha. “Effectiveness of Clove oil massage on Lower Back Pain among Post Natal Mothers at Selected Hospitals, Bangalore.” Asian Journal of Nursing education and research 5.4 (2015): 467-470.

  www.researchgate.net/publication/286523804_Effectiveness_of_Clove_oil_massage_on_Lower_Back_Pain_among_Post_Natal_Mothers_at_Selected_Hospitals_Bangalore

• Cortés-Rojas, Diego Francisco et al. “Clove (Syzygium aromaticum): a precious spice.” Asian Pacific journal of tropical biomedicine vol. 4,2 (2014): 90-6. doi:10.1016/S2221-1691(14)60215-X

  www.ncbi.nlm.nih.gov/pmc/articles/PMC3819475/#b30

• Li, Hai Ying et al. “Eugenol Inhibits ATP-induced P2X Currents in Trigeminal Ganglion Neurons.” The Korean journal of physiology & pharmacology: official journal of the Korean Physiological Society and the Korean Society of Pharmacology vol. 12,6 (2008): 315-21. doi:10.4196/kjpp.2008.12.6.315

  www.ncbi.nlm.nih.gov/pmc/articles/PMC2788653/

• Halder, Sumita, et al. “Acute effect of essential oil of Eugenia caryophyllata on cognition and pain in mice.” Naunyn-Schmiedeberg’s archives of pharmacology 385.6 (2012): 587-593.

  link.springer.com/article/10.1007%2Fs00210-012-0742-2

• Alqareer A, Alyahya A, Andersson L. The effect of clove and benzocaine versus placebo as topical anesthetics. J Dent . 2006;34(10):747‐750.

  pubmed.ncbi.nlm.nih.gov/16530911/

• Duarte, R. C., et al. “Irradiation effect on antifungal potential of clove essential oil.” Science And Technology Against Microbial Pathogens: Research, Development and Evaluation . 2011. 236-240.

  www.worldscientific.com/doi/abs/10.1142/9789814354868_0046

• Santin JR, Lemos M, Klein-Júnior LC, et al. Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal models. Naunyn Schmiedebergs Arch Pharmacol . 2011;383(2):149‐158.

  pubmed.ncbi.nlm.nih.gov/21140134/

• Kumaravelu, Parasakthy, et al. “The antioxidant effect of eugenol on CCl4-induced erythrocyte damage in rats.” The Journal of Nutritional Biochemistry 7.1 (1996): 23-28.

  www.sciencedirect.com/science/article/abs/pii/095528639500162X

• Abdel-Magied, N., and A. G. Ahmed. “Efficacy of clove oil as an antioxidant against radiation risk in male rats.” Journal of Radiation Research and Applied Sciences 4.3 (2011): 939-955.

  inis.iaea.org/search/search.aspx?orig_q=RN:44083430

• Humbal, Brijesh R., et al. “Evaluation of in-vivo anti-inflammatory activity of Syzygium aromaticum oil in male wistar rats.” (2019).

  www.researchgate.net/publication/334735954_Evaluation_of_in-vivo_anti-inflammatory_activity_of_Syzygium_aromaticum_oil_in_male_wistar_rats

• Taher, Yousef A., et al. “Experimental evaluation of anti-inflammatory, antinociceptive and antipyretic activities of clove oil in mice.” Libyan Journal of Medicine 10.1 (2015): 28685.

  www.tandfonline.com/doi/full/10.3402/ljm.v10.28685

• Nuñez, L, and M D’ Aquino. “Microbicide activity of clove essential oil (Eugenia caryophyllata).” Brazilian journal of microbiology: vol. 43,4 (2012): 1255-60.

  www.ncbi.nlm.nih.gov/pmc/articles/PMC3769004/

• Ács, Kamilla et al. “Antibacterial activity evaluation of selected essential oils in liquid and vapor phase on respiratory tract pathogens.” BMC complementary and alternative medicine vol. 18,1 227. 27 Jul. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6064118/
• Santa Packyanathan, Jerusha, and Gopinath Prakasam. “Antibacterial Effect of Clove Oil against Clinical Strains of Escherichia coli.” Journal of Pharmaceutical Sciences and Research 9.7 (2017): 1203.

  search.proquest.com/openview/8bf3b96982be7f97c4f86c4dd8ae3dd9/1?pq-origsite=gscholar&cbl=54977

• Vázquez-Sánchez D, Cabo ML, Rodríguez-Herrera JJ. Antimicrobial activity of essential oils against Staphylococcus aureus biofilms. Food Sci Technol Int . 2015;21(8):559‐570.

  pubmed.ncbi.nlm.nih.gov/25280938/

• Chami N, Bennis S, Chami F, Aboussekhra A, Remmal A. Study of anticandidal activity of carvacrol and eugenol in vitro and in vivo. Oral Microbiol Immunol . 2005;20(2):106‐111.

  pubmed.ncbi.nlm.nih.gov/15720571/

• Kurokawa M, Nagasaka K, Hirabayashi T, et al. Efficacy of traditional herbal medicines in combination with acyclovir against herpes simplex virus type 1 infection in vitro and in vivo. Antiviral Res . 1995;27(1-2):19‐37.

  pubmed.ncbi.nlm.nih.gov/7486956/

• Wu, Shuhua et al. “Protective essential oil attenuates influenza virus infection: an in vitro study in MDCK cells.” BMC complementary and alternative medicine vol. 10 69. 15 Nov. 2010.

  www.ncbi.nlm.nih.gov/pmc/articles/PMC2994788/

• Shapiro, Rochel. “Prevention of vector transmitted diseases with clove oil insect repellent.” Journal of pediatric nursing 27.4 (2012): 346-349.

  www.sciencedirect.com/science/article/abs/pii/S0882596311001898

• Iwamatsu, Takuma, et al. “Identification of repellent odorants to the body louse, Pediculus humanus corporis, in clove essential oil.” Parasitology research 115.4 (2016): 1659-1666.

  link.springer.com/article/10.1007/s00436-016-4905-9

• Park, Il-Kwon, and Sang-Chul Shin. “Fumigant activity of plant essential oils and components from garlic (Allium sativum) and clove bud (Eugenia caryophyllata) oils against the Japanese termite (Reticulitermes speratus Kolbe).” Journal of Agricultural and Food Chemistry 53.11 (2005): 4388-4392.

  pubs.acs.org/doi/abs/10.1021/jf050393r

• Eamsobhana P, Yoolek A, Kongkaew W, et al. Laboratory evaluation of aromatic essential oils from thirteen plant species as candidate repellents against Leptotrombidium chiggers (Acari: Trombiculidae), the vector of scrub typhus. Exp Appl Acarol . 2009;47(3):257‐262.

  pubmed.ncbi.nlm.nih.gov/19009361/

• Hanifah, Azima Laili, et al. “Laboratory evaluation of six crude plant extracts as repellents against larval Leptotrombidium deliense (Acari: Trombiculidae).” Asian Pacific Journal of Tropical Biomedicine 2.1 (2012): S257-S259.

  www.sciencedirect.com/science/article/abs/pii/S2221169112601701

• Sritabutra, Duangkamon, et al. “Evaluation of herbal essential oil as repellents against Aedes aegypti (L.) and Anopheles dirus Peyton & Harrion.” Asian Pacific Journal of Tropical Biomedicine 1.1 (2011): S124-S128.

  www.sciencedirect.com/science/article/abs/pii/S222116911160138X

• Barbosa, Juliana DF, et al. “Structure–activity relationships of eugenol derivatives against Aedes aegypti (Diptera: Culicidae) larvae.” Pest management science 68.11 (2012): 1478-1483.

  onlinelibrary.wiley.com/doi/abs/10.1002/ps.3331

• Kafle L, Shih CJ. Toxicity and repellency of compounds from clove (Syzygium aromaticum) to red imported fire ants Solenopsis invicta (Hymenoptera: Formicidae). J Econ Entomol . 2013;106(1):131‐135.

  pubmed.ncbi.nlm.nih.gov/23448024/

• Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Eugenol (Clove Oil).

  www.ncbi.nlm.nih.gov/books/NBK551727/

• Peixoto-Neves, Dieniffer et al. “Eugenol dilates rat cerebral arteries by inhibiting smooth muscle cell voltage-dependent calcium channels.” Journal of cardiovascular pharmacology vol. 64,5 (2014): 401-6.

  www.ncbi.nlm.nih.gov/pmc/articles/PMC4224997/

• Lahlou, Saad, et al. “Cardiovascular effects of eugenol, a phenolic compound present in many plant essential oils, in normotensive rats.” Journal of cardiovascular pharmacology 43.2 (2004): 250-257.

  www.researchgate.net/publication/8925226_Cardiovascular_Effects_of_Eugenol_A_Phenolic_Compound_Present_in_Many_Plant_Essential_Oils_in_Normotensive_Rats

• Al-Okbi, Sahar Y., et al. “Protective effect of clove oil and eugenol microemulsions on fatty liver and dyslipidemia as components of metabolic syndrome.” Journal of medicinal food 17.7 (2014): 764-771.

  pubmed.ncbi.nlm.nih.gov/24611461/

• Shukri, Radhiah, Suhaila Mohamed, and Noordin Mohamed Mustapha. “Cloves protect the heart, liver and lens of diabetic rats.” Food chemistry 122.4 (2010): 1116-1121.

  www.sciencedirect.com/science/article/abs/pii/S0308814610003870

• Peixoto‐Neves, Dieniffer, et al. “Eugenol dilates mesenteric arteries and reduces systemic BP by activating endothelial cell TRPV 4 channels.” British journal of pharmacology 172.14 (2015): 3484-3494.

  pubmed.ncbi.nlm.nih.gov/25832173/

• Shahtalebi, Mohammad Ali, Atefeh Sadat-Hosseini, and Leila Safaeian. “Preparation and evaluation of clove oil in emu oil self-emulsion for hair conditioning and hair loss prevention.” Journal of HerbMed Pharmacology 5 (2016).

  www.researchgate.net/publication/301204003_Preparation_and_evaluation_of_clove_oil_in_emu_oil_self-emulsion_for_hair_conditioning_and_hair_loss_prevention

• Aggarwal BB, Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol . 2006;71(10):1397‐1421.

  pubmed.ncbi.nlm.nih.gov/16563357/

• Ghosh, Rita, et al. “Eugenol Causes Melanoma Growth Suppression through Inhibition of E2F1 Transcriptional Activity.” Journal of Biological Chemistry , 18 Feb. 2005, www.jbc.org/content/280/7/5812.short.
• National Toxicology Program. Carcinogenesis Studies of Eugenol (CAS No. 97-53-0) in F344/N Rats and B6C3F1 Mice (Feed Studies). Natl Toxicol Program Tech Rep Ser . 1983;223:1‐159.

  pubmed.ncbi.nlm.nih.gov/12778213/

• Liu, Haizhou et al. “Clove extract inhibits tumor growth and promotes cell cycle arrest and apoptosis.” Oncology research vol. 21,5 (2014): 247-59.

  www.ncbi.nlm.nih.gov/pmc/articles/PMC4132639/

• Atsumi, T., et al. “A Comparative Study of the Antioxidant/Prooxidant Activities of Eugenol and Isoeugenol with Various Concentrations and Oxidation Conditions.” Toxicology in Vitro , Pergamon, 17 June 2005, www.sciencedirect.com/science/article/abs/pii/S088723330500072X.

  www.citationmachine.net/bibliographies/616422860?new=true

• Tajuddin et al. “Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: a comparative study.” BMC complementary and alternative medicine vol. 3 6. 20 Oct. 2003.

  www.ncbi.nlm.nih.gov/pmc/articles/PMC270058/

• Tajuddin et al. “Effect of 50% ethanolic extract of Syzygium aromaticum (L.) Merr. & Perry. (clove) on sexual behaviour of normal male rats.” BMC complementary and alternative medicine vol. 4 17. 5 Nov. 2004.

  www.ncbi.nlm.nih.gov/pmc/articles/PMC534794/

• Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Eugenol (Clove Oil).

  www.ncbi.nlm.nih.gov/books/NBK551727/

• Gülçin, İlhami, et al. “Antioxidant Activity of Clove Oil – A Powerful Antioxidant Source.” Arabian Journal of Chemistry , Elsevier, 19 Sept. 2010, www.sciencedirect.com/science/article/pii/S1878535210001899.
• Thompson DC, Constantin-Teodosiu D, Moldéus P. Metabolism and cytotoxicity of eugenol in isolated rat hepatocytes. Chem Biol Interact . 1991;77(2):137‐147.

  pubmed.ncbi.nlm.nih.gov/1991333/

• Mizutani T, Satoh K, Nomura H, Nakanishi K. Hepatotoxicity of eugenol in mice depleted of glutathione by treatment with DL-buthionine sulfoximine. Res Commun Chem Pathol Pharmacol . 1991;71(2):219‐230.

  pubmed.ncbi.nlm.nih.gov/2047567/

• Barkin ME, Boyd JP, Cohen S. Acute allergic reaction to eugenol. Oral Surg Oral Med Oral Pathol . 1984;57(4):441‐442.

  pubmed.ncbi.nlm.nih.gov/6584843/

• Tammannavar P, Pushpalatha C, Jain S, Sowmya SV. An unexpected positive hypersensitive reaction to eugenol. BMJ Case Rep . 2013;2013:bcr2013009464. Published 2013 Sep 18.

  pubmed.ncbi.nlm.nih.gov/24049087/

• Klein AH, Carstens MI, Carstens E. Eugenol and carvacrol induce temporally desensitizing patterns of oral irritation and enhance innocuous warmth and noxious heat sensation on the tongue. Pain . 2013;154(10):2078‐2087.

  pubmed.ncbi.nlm.nih.gov/23791894/

• Srivastava, K.C., and N. Malhotra. “Acetyl Eugenol, a Component of Oil of Cloves (Syzygium Aromaticum L.) Inhibits Aggregation and Alters Arachidonic Acid Metabolism in Human Blood Platelets.” Prostaglandins, Leukotrienes and Essential Fatty Acids , Churchill Livingstone, 3 Apr. 2004.

  www.sciencedirect.com/science/article/abs/pii/095232789190070L

• Srivastava, K.C. “Antiplatelet Principles from a Food Spice Clove (Syzgium Aromaticum L).” Prostaglandins, Leukotrienes and Essential Fatty Acids , Churchill Livingstone, 3 Apr. 2004.

  www.sciencedirect.com/science/article/abs/pii/095232789390116E

• Hartnoll G, Moore D, Douek D. Near fatal ingestion of oil of cloves. Arch Dis Child . 1993;69(3):392‐393.

  pubmed.ncbi.nlm.nih.gov/8215554/